TargetMol

MRT68921 dihydrochloride

Product Code:
 
TAR-T9142
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T9142-2mg2mg£99.00
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TAR-T9142-5mg5mg£115.00
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TAR-T9142-10mg10mg£146.00
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TAR-T9142-25mg25mg£229.00
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TAR-T9142-50mg50mg£357.00
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TAR-T9142-100mg100mg£446.00
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TAR-T9142-200mg200mg£622.00
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This product comes from: United States.
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Further Information

Bioactivity:
MRT68921 dihydrochloride is a potent ULK1 and ULK2 inhibitor (IC50 of 2.9 nM and 1.1 nM, respectively).
CAS:
2080306-21-2
Formula:
C25H36Cl2N6O
Molecular Weight:
507.5
Pathway:
Autophagy
Purity:
0.9898
SMILES:
Cl.Cl.CN1CCc2cc(Nc3ncc(C4CC4)c(NCCCNC(=O)C4CCC4)n3)ccc2C1
Target:
Autophagy

References

Petherick KJ, et al. Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. J Biol Chem. 2015 May 1;290(18):11376-83. Chen Y , Xie X , Wang C , et al. Dual Targeting of NUAK1 and ULK1 Using the Multitargeted Inhibitor MRT68921 Exerts Potent Antitumor Activities[J]. SSRN Electronic Journal, 2019.