TargetMol

KN-92 hydrochloride

Product Code:
 
TAR-T8543
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8543-1mg1mg£122.00
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TAR-T8543-2mg2mg£144.00
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TAR-T8543-5mg5mg£217.00
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TAR-T8543-1mL1 mL * 10 mM (in DMSO)£230.00
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TAR-T8543-10mg10mg£290.00
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TAR-T8543-25mg25mg£470.00
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TAR-T8543-50mg50mg£651.00
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TAR-T8543-100mg100mg£863.00
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Further Information

Bioactivity:
KN-92 hydrochloride is an inactive derivative of KN-93. KN-93 is a selective Ca2+/calmodulin-dependent kinase II (CaMKII) inhibitor, competitively blocking CaM binding to the kinase with Ki of 370 nM.
CAS:
1431698-47-3
Formula:
C24H26Cl2N2O3S
Molecular Weight:
493.44
Pathway:
Neuroscience
Purity:
0.9971
SMILES:
Cl.COc1ccc(cc1)S(=O)(=O)Nc1ccccc1CN(C)CC=Cc1ccc(Cl)cc1
Target:
CaMK

References

Rezazadeh S, Claydon TW, Fedida D. et al. KN-93 (2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated potassium channels. J Pharmacol Exp Ther. 2006 Apr;317(1):292-9. Rokhlin OW, Guseva NV, Taghiyev AF et al. KN-93 inhibits androgen receptor activity and induces cell death irrespective of p53 and Akt status in prostate cancer. Cancer Biol Ther. 2010 Feb;9(3):224-35. Gao L, Blair LA, Marshall J. et al. CaMKII-independent effects of KN93 and its inactive analog KN92: reversible inhibition of L-type calcium channels. Biochem Biophys Res Commun. 2006 Jul 14;345(4):1606-10.