TargetMol

MAZ51

Product Code:
 
TAR-T8496
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8496-1mg1mg£98.00
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TAR-T8496-2mg2mg£108.00
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TAR-T8496-1mL1 mL * 10 mM (in DMSO)£113.00
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TAR-T8496-5mg5mg£132.00
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TAR-T8496-10mg10mg£172.00
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TAR-T8496-25mg25mg£275.00
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TAR-T8496-50mg50mg£414.00
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TAR-T8496-100mg100mg£584.00
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This product comes from: United States.
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Further Information

Bioactivity:
MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.
CAS:
163655-37-6
Formula:
C21H18N2O
Molecular Weight:
314.388
Pathway:
Apoptosis; Tyrosine Kinase/Adaptors; Angiogenesis
Purity:
0.9853
SMILES:
CN(C)c1ccc(C=C2C(=O)Nc3ccccc23)c2ccccc12
Target:
Apoptosis; VEGFR

References

Kirkin V, et al. MAZ51, an indolinone that inhibits endothelial cell and tumor cell growth in vitro, suppresses tumor growth in vivo. Int J Cancer. 2004 Dec 20;112(6):986-93. Kirkin V, et al. Characterization of indolinones which preferentially inhibit VEGF-C- and VEGF-D-induced activation of VEGFR-3 rather than VEGFR-2. Eur J Biochem. 2001 Nov;268(21):5530-40.