TargetMol

Yoda 1

Product Code:
 
TAR-T7506
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T7506-1mg1mg£102.00
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TAR-T7506-2mg2mg£115.00
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TAR-T7506-5mg5mg£140.00
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TAR-T7506-1mL1 mL * 10 mM (in DMSO)£147.00
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TAR-T7506-10mg10mg£164.00
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TAR-T7506-25mg25mg£266.00
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TAR-T7506-50mg50mg£448.00
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TAR-T7506-100mg100mg£624.00
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TAR-T7506-500mg500mg£1,243.00
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Further Information

Bioactivity:
Yoda1 is a Piezo1 ion channel agonist (EC50s = 17.1 and 26.6 μM for murine and human Piezo1-transfected HEK293T cells, respectively)
CAS:
448947-81-7
Formula:
C13H8Cl2N4S2
Molecular Weight:
355.26
Pathway:
Membrane transporter/Ion channel
Purity:
0.9998
SMILES:
Clc1cccc(Cl)c1CSc1nnc(s1)-c1cnccn1
Target:
Piezo Channel

References

Davies JE, Lopresto D, Apta BHR,et al.Using Yoda-1 to mimic laminar flow in vitro: A tool to simplify drug testing[J].Biochem Pharmacol. 2019 Oct;168:473-480. Ruhma S , Jie X , Dubin A E , et al. Chemical activation of the mechanotransduction channel Piezo1[J]. eLife, 2015, 4. Zheng Q, Zou Y, Teng P, et al. Mechanosensitive Channel PIEZO1 Senses Shear Force to Induce KLF2/4 Expression via CaMKII/MEKK3/ERK5 Axis in Endothelial Cells. Cells. 2022, 11(14): 2191 Chen L, Yan Y, Kong F, et al. Contribution of Oxidative Stress Induced by Sonodynamic Therapy to the Calcium Homeostasis Imbalance Enhances Macrophage Infiltration in Glioma Cells. Cancers. 2022, 14(8): 2036