TargetMol

ONC212

Product Code:
 
TAR-T7398
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T7398-1mg1mg£106.00
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TAR-T7398-1mL1 mL * 10 mM (in DMSO)£148.00
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TAR-T7398-5mg5mg£149.00
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TAR-T7398-10mg10mg£201.00
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TAR-T7398-25mg25mg£291.00
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TAR-T7398-50mg50mg£425.00
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Quantity:
TAR-T7398-100mg100mg£592.00
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This product comes from: United States.
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Further Information

Bioactivity:
ONC212, a fluorinated-ONC201 analogue, is a selective agonist of GPR132.
CAS:
1807861-48-8
Formula:
C24H23F3N4O
Molecular Weight:
440.47
Pathway:
Apoptosis; GPCR/G Protein; Endocrinology/Hormones
Purity:
0.98
SMILES:
FC(F)(F)c1ccc(CN2C3=NCCN3C3=C(CN(Cc4ccccc4)CC3)C2=O)cc1
Target:
Apoptosis; GPR

References

Lev A , Lulla A R , Wagner J , et al. Anti-pancreatic cancer activity of ONC212 involves the unfolded protein response (UPR) and is reduced by IGF1-R and GRP78/BIP.[J]. Oncotarget, 2017, 8(47):81776-81793. Nii T, Prabhu VV, Ruvolo V,et al.Imipridone ONC212 activates orphan G protein-coupled receptor GPR132 and integrated stress response in acute myeloid leukemia[J].Leukemia. 2019 Dec;33(12):2805-2816. Wei B, Zhang T, Wang P, et al. Anti-infective therapy using species-specific activators of Staphylococcus aureus ClpP. Nature Communications. 2022, 13(1): 1-16.