TargetMol

GSK805

Product Code:
 
TAR-T7388
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T7388-2mg2mg£128.00
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TAR-T7388-5mg5mg£170.00
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TAR-T7388-1mL1 mL * 10 mM (in DMSO)£188.00
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TAR-T7388-10mg10mg£229.00
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TAR-T7388-25mg25mg£389.00
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TAR-T7388-50mg50mg£461.00
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TAR-T7388-100mg100mg£630.00
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TAR-T7388-200mg200mg£871.00
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TAR-T7388-500mg500mg£1,476.00
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This product comes from: United States.
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Further Information

Bioactivity:
GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor's putative ligand binding domain without exerting significant effects on DNA binding
CAS:
1426802-50-7
Formula:
C23H18Cl2F3NO4S
Molecular Weight:
532.36
Pathway:
Metabolism
Purity:
0.98
SMILES:
CCS(=O)(=O)c1ccc(CC(=O)Nc2cc(Cl)c(c(Cl)c2)-c2ccccc2OC(F)(F)F)cc1
Target:
ROR

References

Xiao S , Yosef N , Yang J , et al. Small-Molecule ROR?t Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent Mechanisms[J]. Immunity, 2014, 40(4):477-489. Discovery of Biaryl Amides as Potent, Orally Bioavailable, and CNS Penetrant ROR?t Inhibitors[J]. ACS Medicinal Chemistry Letters:-.