TargetMol

Gemigliptin Tartrate(911637-19-9 free base)

Product Code:
 
TAR-T7369L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T7369L-2mg2mg£98.00
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TAR-T7369L-5mg5mg£115.00
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TAR-T7369L-10mg10mg£142.00
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TAR-T7369L-1mL1 mL * 10 mM (in DMSO)£148.00
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TAR-T7369L-25mg25mg£198.00
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TAR-T7369L-50mg50mg£289.00
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Further Information

Bioactivity:
Gemigliptin tartrate is a highly selective, reversible and competitive inhibitor of dipeptidyl peptidase-4 (DPP-4). It has an IC50 of 10.3 nM for human recombinant DPP-4. Gemigliptin tartrate exhibits potent anti-glycation properties.
CAS:
1374639-74-3
Formula:
C22H25F8N5O8
Molecular Weight:
639.45
Pathway:
Proteases/Proteasome; Ubiquitination
Purity:
0.98
SMILES:
O=C([C@@H]([C@H](C(O)=O)O)O)O.O=C1N(CC(F)(CC1)F)C[C@H](CC(N2CCC3=C(N=C(N=C3C2)C(F)(F)F)C(F)(F)F)=O)N
Target:
Proteasome; DPP-4

References

Jung E , Kim J , Kim S H , et al. Gemigliptin, a novel dipeptidyl peptidase-4 inhibitor, exhibits potent anti-glycation properties in vitro and in vivo.[J]. European Journal of Pharmacology, 2014, 744:98-102. Kim S H , Jung E , Yoon M K , et al. Pharmacological profiles of gemigliptin (LC15-0444), a novel dipeptidyl peptidase-4 inhibitor, in vitro and in vivo[J]. European Journal of Pharmacology, 2016, 788:54-64.