TargetMol

LIXIVAPTAN

Product Code:
 
TAR-T7303
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T7303-1mg1mg£99.00
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TAR-T7303-2mg2mg£112.00
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TAR-T7303-5mg5mg£130.00
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TAR-T7303-1mL1 mL * 10 mM (in DMSO)£133.00
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TAR-T7303-10mg10mg£174.00
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TAR-T7303-25mg25mg£281.00
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TAR-T7303-50mg50mg£429.00
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TAR-T7303-100mg100mg£598.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
Lixivaptan is an orally active and selective vasopressin receptor V2 antagonist(Ki = 2.3 nM)
CAS:
168079-32-1
Formula:
C27H21ClFN3O2
Molecular Weight:
473.93
Pathway:
GPCR/G Protein
Purity:
0.9933
SMILES:
Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc23)c(Cl)c1
Target:
Vasopressin Receptor

References

Di Mise A, Venneri M, Ranieri M.et al.Lixivaptan, a New Generation Diuretic, Counteracts Vasopressin-Induced Aquaporin-2 Trafficking and Function in Renal Collecting Duct Cells.Int J Mol Sci. 2019 Dec 26;21(1). Wang X, Constans MM, Chebib FT.et al.Effect of a Vasopressin V2 Receptor Antagonist on Polycystic Kidney Disease Development in a Rat Model[J].Am J Nephrol. 2019;49(6):487-493.