TargetMol

GS-441524

Product Code:
 
TAR-T7222
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T7222-1mL1 mL * 10 mM (in DMSO)£95.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T7222-50mg50mg£117.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T7222-100mg100mg£147.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
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Further Information

Bioactivity:
GS-441524 treatment of cats with naturally occurring feline infectious peritonitis.
CAS:
1191237-69-0
Formula:
C12H13N5O4
Molecular Weight:
291.267
Pathway:
Microbiology/Virology; ; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
Purity:
0.999
SMILES:
Nc1ncnn2c(ccc12)[C@@]1(O[C@H](CO)[C@@H](O)[C@H]1O)C#N
Target:
SARS-CoV; DNA/RNA Synthesis

References

Mohseni N, Royster A, Ren S, et al.A novel compound targets the feline infectious peritonitis virus nucleocapsid protein and inhibits viral replication in cell culture.Journal of Biological Chemistry.2023: 102976. Wang Q, Wu J, Wang H, et al. Structural basis for RNA replication by the SARS-CoV-2 polymerase. Cell. 2020, 182(2): 417-428. e13. Bennett R P, Postnikova E N, Eaton B P, et al. Sangivamycin is highly effective against SARS-CoV-2 in vitro and has favorable drug properties. JCI insight. 2022, 7(1). Xu L, Tan B, Huang D, et al. Remdesivir inhibits renal fibrosis in obstructed kidneys[J]. bioRxiv. 2020. Pedersen N C , Perron M , Bannasch M , et al. Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis[J]. Journal of Feline Medicine & Surgery, 2019. Xu L, Tan B, Huang D, et al. Remdesivir Inhibits Tubulointerstitial Fibrosis in Obstructed Kidneys. Frontiers in Pharmacology. 2021, 12: 1668. Xu L, Tan B, Huang D, et al. Remdesivir inhibits renal fibrosis in obstructed kidneys. Frontiers in Pharmacology. 2021, 12: 1668 Murphy B G , Perron M , Murakami E , et al. The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies[J]. Veterinary Microbiology, 2018, 219:226-233. Wang Q, Wu J, Wang H, et al. Structural basis for RNA replication by the SARS-CoV-2 polymerase[J]. Cell. 2020.