TargetMol

Schisandrol B

Product Code:
 
TAR-T6S1917
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6S1917-5mg5mg£123.00
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TAR-T6S1917-1mL1 mL * 10 mM (in DMSO)£128.00
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TAR-T6S1917-10mg10mg£148.00
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TAR-T6S1917-25mg25mg£241.00
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TAR-T6S1917-50mg50mg£326.00
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TAR-T6S1917-100mg100mg£453.00
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Quantity:
TAR-T6S1917-500mg500mg£946.00
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Further Information

Bioactivity:
1. Gomisin A may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs signaling pathways. 2. Gomisin A has anti-inflammatory property, potentially result from the inhibition of COX-2, iNOS, IL-6, TNF-α and NO through the down-regulation of RIP2 and NF-κB activation. 3. Gomisin A induces marked protective effects against hepatic and renal injury induced by CCl(4) exposure through differential regulation of the MAPK signal transduction pathway. 4. Gomisin A significantly inhibits cell proliferation in a dose-dependent manner, due to cell cycle arrest in the G1 phase with the downregulation of cyclin D1 expression and Retinoblastoma (RB) phosphorylation.
CAS:
58546-54-6
Formula:
C23H28O7
Molecular Weight:
416.47
Pathway:
Autophagy; Immunology/Inflammation; NF-κb; Metabolism
Purity:
0.9932
SMILES:
COc1cc2C[C@](C)(O)[C@@H](C)Cc3cc4OCOc4c(OC)c3-c2c(OC)c1OC
Target:
P45; Reactive Oxygen Species; Autophagy

References

Hwang, Dae. Protective effects of gomisin A isolated from Schisandra chinensis against CCl4-induced hepatic and renal injury[J]. International Journal of Molecular Medicine, 2013, 31(4):888---898.