TargetMol

Quisinostat dihydrochloride

Product Code:
 
TAR-T6865
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6865-1mg1mg£118.00
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TAR-T6865-5mg5mg£174.00
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TAR-T6865-1mL1 mL * 10 mM (in DMSO)£177.00
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TAR-T6865-10mg10mg£253.00
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TAR-T6865-25mg25mg£351.00
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TAR-T6865-50mg50mg£438.00
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TAR-T6865-100mg100mg£600.00
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Further Information

Bioactivity:
Quisinostat (JNJ-26481585) 2HCl is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lowest potency to HDACs 6 and 7. Phase 2.
CAS:
875320-31-3
Formula:
C21H28Cl2N6O2
Molecular Weight:
467.4
Pathway:
Apoptosis; Chromatin/Epigenetic; Autophagy; DNA Damage/DNA Repair
Purity:
0.985
SMILES:
Cl.Cl.Cn1cc(CNCC2CCN(CC2)c2ncc(cn2)C(=O)NO)c2ccccc12
Target:
Apoptosis; HDAC; Autophagy

References

Arts J, et al. Clin Cancer Res, 2009, 15(22), 6841-6851. St?hmer T, et al. Br J Haematol 2010, 149(4), 529-536