TargetMol

Uprosertib

Product Code:
 
TAR-T6849
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6849-2mg2mg£114.00
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TAR-T6849-5mg5mg£132.00
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TAR-T6849-1mL1 mL * 10 mM (in DMSO)£159.00
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TAR-T6849-10mg10mg£172.00
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TAR-T6849-25mg25mg£241.00
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TAR-T6849-50mg50mg£344.00
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Quantity:
TAR-T6849-100mg100mg£523.00
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This product comes from: United States.
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Further Information

Bioactivity:
Uprosertib (GSK2141795) is a selective, ATP-competitive, and orally bioavailable Akt inhibitor with IC50 of 180 nM, 328 nM, and 38 nM for Akt 1, 2 and 3, respectively. Phase 2.
CAS:
1047634-65-0
Formula:
C18H16Cl2F2N4O2
Molecular Weight:
429.25
Pathway:
PI3K/Akt/mTOR signaling; Cytoskeletal Signaling
Purity:
0.9954
SMILES:
Cn1ncc(Cl)c1-c1cc(oc1Cl)C(=O)N[C@H](CN)Cc1ccc(F)c(F)c1
Target:
Akt

References

Cheraghchi-Bashi A, et al. Oncotarget. 2015, 6(39), 41736-41749. Pachl F, et al. J Proteome Res. 2013, 12(8), 3792-3800. Dumble M, et al. PLoS One. 2014, 9(6):e1200880. Bing S, Xiang S, Xia Z, et al.AKT inhibitor Hu7691 induces differentiation of neuroblastoma cells.Acta Pharmaceutica Sinica B.2023