TargetMol

Butein

Product Code:
 
TAR-T6427
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6427-1mg1mg£99.00
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TAR-T6427-2mg2mg£111.00
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TAR-T6427-1mL1 mL * 10 mM (in DMSO)£134.00
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TAR-T6427-5mg5mg£135.00
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TAR-T6427-10mg10mg£157.00
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TAR-T6427-25mg25mg£251.00
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TAR-T6427-50mg50mg£362.00
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TAR-T6427-100mg100mg£535.00
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This product comes from: United States.
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Further Information

Bioactivity:
Butein, a plant polyphenol, is isolated from Rhus verniciflua. It can inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, and also can inhibit EGFR.
CAS:
487-52-5
Formula:
C15H12O5
Molecular Weight:
272.256
Pathway:
Angiogenesis; Metabolism; ; Autophagy; Tyrosine Kinase/Adaptors; Apoptosis; JAK/STAT signaling
Purity:
0.9985
SMILES:
Oc1ccc(C(=O)C=Cc2ccc(O)c(O)c2)c(O)c1
Target:
Apoptosis; EGFR; PDE; Autophagy

References

Lee SH, et al. Biochem Biophys Res Commun, 2004 , 323(1), 125-132. Rajendran P, et al. Clin Cancer Res, 2011, 17(6), 1425-1439. Pandey MK, et al. J Biol Chem, 2007, 282(24), 17340-17350. Zhang L, et al. FEBS Lett, 2008, 582(13), 1821-1828. Zhang L, et al. Butein sensitizes HeLa cells to cisplatin through the AKT and ERK/p38 MAPK pathways by targeting FoxO3a.Int J Mol Med. 2015 Oct;36(4):957-66. Yang EB, et al. Biochem Biophys Res Commun, 1998, 17, 245(2), 435-438. Zhao L, Zhang W, Luan F, et al.Butein suppresses PD-L1 expression via downregulating STAT1 in non-small cell lung cancer.Biomedicine & Pharmacotherapy.2023, 157: 114030.