TargetMol

Go 6983

Product Code:
 
TAR-T6313
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
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CodeSizePrice
TAR-T6313-1mg1mg£99.00
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Quantity:
TAR-T6313-2mg2mg£111.00
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TAR-T6313-5mg5mg£132.00
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TAR-T6313-1mL1 mL * 10 mM (in DMSO)£135.00
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TAR-T6313-10mg10mg£173.00
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TAR-T6313-25mg25mg£278.00
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TAR-T6313-50mg50mg£398.00
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Quantity:
TAR-T6313-100mg100mg£547.00
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This product comes from: United States.
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Further Information

Bioactivity:
Go 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ, PKCδ and PKCζ with IC50 of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM, respectively.
CAS:
133053-19-7
Formula:
C26H26N4O3
Molecular Weight:
442.519
Pathway:
Cytoskeletal Signaling; Chromatin/Epigenetic
Purity:
0.9904
SMILES:
COc1ccc2n(CCCN(C)C)cc(C3=C(C(=O)NC3=O)c3c[nH]c4ccccc34)c2c1
Target:
PKC

References

Wang D, Wang Y, Di X, et al.Cortical tension drug screen links mitotic spindle integrity to Rho pathway.Current Biology.2023 Peterman EE, et al. J Cardiovasc Pharmacol, 2004, 43(5), 645-656. Zhang Y, Wang Z, Cao J, et al. A Green and Blue Monochromatic Light Combination Therapy Reduces Oxidative Stress and Enhances B-Lymphocyte Proliferation through Promoting Melatonin Secretion. Oxidative Medicine and Cellular Longevity. 2021, 2021. Gschwendt M, et al. FEBS Lett, 1996, 392(2), 77-80. Andresen BT, et al. Hypertension, 2001, 37(2 Part 2), 635-639. Fan Y L, Li B, Zhao H P, et al. A function of fascin1 in the colony formation of mouse embryonic stem cells. Stem Cells. 2020, 38(9): 1078-1090 Fan Y L, Li B, Zhao H P, et al. A function of fascin1 in the colony formation of mouse embryonic stem cells[J]. STEM CELLS. 2020. Kumar A, et al. J Biol Chem, 2004, 279(23), 24255-24264. Young LH, et al. Cardiovasc Drug Rev, 2005, 23(3), 255-272. Ning S, Wang Z, Cao J, et al. Mel1c Mediated Monochromatic Light-Stimulated IGF-I Synthesis through the Intracellular G?q/PKC/ERK Signaling Pathway. International journal of molecular sciences. 2019, 20(7): 1682. Zhang Y, Wang Z, Cao J, et al. A Green and Blue Monochromatic Light Combination Therapy Reduces Oxidative Stress and Enhances B-Lymphocyte Proliferation through Promoting Melatonin Secretion[J]. Oxidative Medicine and Cellular Longevity. 2021, 2021. Zhang Y, Wang Z, Cao J, et al. Physiological crosstalk between the Mel1a and Mel1c pathways modulates melatonin-mediated, monochromatic light combination-induced bursa B-lymphocyte proliferation in chickens[J]. 2020