TargetMol

CCT128930 hydrochloride

Product Code:
 
TAR-T6303L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6303L-1mg1mg£114.00
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TAR-T6303L-2mg2mg£132.00
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TAR-T6303L-5mg5mg£165.00
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TAR-T6303L-1mL1 mL * 10 mM (in DMSO)£185.00
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TAR-T6303L-10mg10mg£229.00
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TAR-T6303L-25mg25mg£388.00
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TAR-T6303L-50mg50mg£546.00
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TAR-T6303L-100mg100mg£749.00
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Further Information

Bioactivity:
CCT128930 hydrochloride is a potent and selective inhibitor of AKT with IC50 of 6 nM. CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophagy. CCT128930 hydrochloride has 28-fold selectivity over the closely related PKA kinase (IC50: 168 nM) through the targeting of Met282 of AKT, as well as 20-fold selectivity over p70S6K (IC50: 120 nM).
CAS:
2453324-32-6
Formula:
C18H21Cl2N5
Molecular Weight:
378.3
Pathway:
PI3K/Akt/mTOR signaling; Apoptosis; Autophagy; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
Purity:
0.98
SMILES:
Cl.NC1(Cc2ccc(Cl)cc2)CCN(CC1)c1ncnc2[nH]ccc12
Target:
Apoptosis; Akt; PKA; mTOR; Autophagy

References

Wang FZ, et al. CCT128930 induces cell cycle arrest, DNA damage, and autophagy independent of Akt inhibition. Biochimie. 2014;103:118-125. Yap TA et al. Preclinical pharmacology, antitumor activity, and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930. Mol Cancer Ther. 2011 Feb;10(2):360-71.