TargetMol

LFM-A13

Product Code:
 
TAR-T6217
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6217-2mg2mg£95.00
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TAR-T6217-1mL1 mL * 10 mM (in DMSO)£108.00
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TAR-T6217-5mg5mg£108.00
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TAR-T6217-10mg10mg£130.00
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TAR-T6217-25mg25mg£205.00
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TAR-T6217-50mg50mg£298.00
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Quantity:
TAR-T6217-100mg100mg£455.00
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Further Information

Bioactivity:
LFM-A13?IC50=2.5 μM?, a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and IRK.
CAS:
244240-24-2
Formula:
C11H8Br2N2O2
Molecular Weight:
360.005
Pathway:
Cell Cycle/Checkpoint; JAK/STAT signaling; Angiogenesis; Stem Cells; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors
Purity:
0.999
SMILES:
CC(O)=C(/C#N)C(=O)Nc1cc(Br)ccc1Br
Target:
PLK; JAK; BTK

References

Uckun FM, et al. Clin Cancer Res. 2002, 8(5), 1224-1233. Mahajan S, et al. J Biol Chem. 1999, 274(14), 9587-9599. Wan J, Yu X, Niu J Q, et al. Inhibition of Bruton's Tyrosine Kinase Protects Against Burn Sepsis-Induced Intestinal Injury. Frontiers in Medicine. 2022, 9. Bam R, et al. Am J Hematol. 2013, 88(6), 463-471. Gilbert C, et al. J Immunol. 2003, 170(10), 5235-5243.