TargetMol

UMI-77

Product Code:
 
TAR-T6034
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6034-2mg2mg£113.00
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TAR-T6034-1mL1 mL * 10 mM (in DMSO)£139.00
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TAR-T6034-5mg5mg£139.00
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TAR-T6034-10mg10mg£172.00
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TAR-T6034-25mg25mg£255.00
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TAR-T6034-50mg50mg£367.00
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TAR-T6034-100mg100mg£497.00
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Further Information

Bioactivity:
UMI-77, a specific Mcl-1 inhibitor (Ki: 490 nM), has selectivity over other members of Bcl-2 family.
CAS:
518303-20-3
Formula:
C18H14BrNO5S2
Molecular Weight:
468.34
Pathway:
Apoptosis
Purity:
0.9957
SMILES:
OC(=O)CSc1cc(NS(=O)(=O)c2ccc(Br)cc2)c2ccccc2c1O
Target:
BCL

References

Xu Y, Chen Q, Jiang Y, et al.UMI-77 Modulates the Complement Cascade Pathway and Inhibits Inflammatory Factor Storm in Sepsis Based on TMT Proteomics and Inflammation Array Glass Chip.Journal of Proteome Research.2023 Abulwerdi F, et al. Mol Cancer Ther. 2014, 13(3), 565-575. Cen X, Chen Y, Xu X, et al. Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer?s disease mouse model[J]. Nature Communications . 2020, 11(1): 1-13. Cen X, Chen Y, Xu X, et al. Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer?s disease mouse model. Nature Communications. 2020, 11(1): 1-13.