TargetMol

HS-243

Product Code:
 
TAR-T60012
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T60012-1mg1mg£109.00
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TAR-T60012-5mg5mg£161.00
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TAR-T60012-10mg10mg£229.00
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TAR-T60012-25mg25mg£389.00
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TAR-T60012-50mg50mg£544.00
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TAR-T60012-100mg100mg£748.00
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This product comes from: United States.
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Further Information

Bioactivity:
HS-243 is an inhibitor of IRAK-4 and IRAK-1 with IC50s of 20 and 24 nM. HS-243 shows anti-inflammatory and anticancer activity.
CAS:
848249-10-5
Formula:
C17H16N4O3
Molecular Weight:
324.34
Pathway:
MAPK; NF-κb; Immunology/Inflammation; Cell Cycle/Checkpoint
Purity:
0.9734
SMILES:
CCCn1c(NC(=O)c2cccc(c2)[N+]([O-])=O)nc2ccccc12
Target:
IRAK; MAPK; CDK

References

Scarneo SA, et al. A highly selective inhibitor of interleukin-1 receptor-associated kinases 1/4 (IRAK-1/4) delineates the distinct signaling roles of IRAK-1/4 and the TAK1 kinase. J Biol Chem. 2020 Feb 7;295(6):1565-1574.