TargetMol

INCB-057643

Product Code:
 
TAR-T5417
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5417-1mg1mg£125.00
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TAR-T5417-2mg2mg£149.00
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TAR-T5417-5mg5mg£206.00
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TAR-T5417-1mL1 mL * 10 mM (in DMSO)£217.00
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TAR-T5417-10mg10mg£303.00
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TAR-T5417-25mg25mg£535.00
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TAR-T5417-50mg50mg£736.00
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TAR-T5417-100mg100mg£994.00
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Quantity:
TAR-T5417-500mg500mg£1,910.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
INCB057643 is a potent, selective and orally bioavailable BET inhibitor.
CAS:
1820889-23-3
Formula:
C20H21N3O5S
Molecular Weight:
415.46
Pathway:
Apoptosis; Chromatin/Epigenetic
Purity:
0.9958
SMILES:
CN1C(=O)C(C)(C)Oc2c1cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)S(C)(=O)=O
Target:
Apoptosis; Epigenetic Reader Domain

References

Wilson AJ, et al. The BET inhibitor INCB054329 reduces homologous recombination efficiency and augments PARP inhibitor activity in ovarian cancer. Gynecol Oncol. 2018 Jun;149(3):575-584. Matthew C. Stubbs, et al. Abstract 5071: Preclinical characterization of the potent and selective BET inhibitor INCB057643 in models of hematologic malignancies. AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 5071.