TargetMol

TR-14035

Product Code:
 
TAR-T5310
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5310-1mg1mg£136.00
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TAR-T5310-2mg2mg£164.00
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TAR-T5310-5mg5mg£213.00
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TAR-T5310-1mL1 mL * 10 mM (in DMSO)£222.00
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TAR-T5310-10mg10mg£303.00
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TAR-T5310-25mg25mg£490.00
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TAR-T5310-50mg50mg£678.00
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TAR-T5310-100mg100mg£922.00
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This product comes from: United States.
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Further Information

Bioactivity:
TR-14035 is a dual antagonist of α4β7/α4β1 integrins (IC50s: 7/87nM).
CAS:
232271-19-1
Formula:
C24H21Cl2NO5
Molecular Weight:
474.33
Pathway:
Cytoskeletal Signaling
Purity:
0.9981
SMILES:
COc1cccc(OC)c1-c1ccc(C[C@H](NC(=O)c2c(Cl)cccc2Cl)C(O)=O)cc1
Target:
Integrin

References

Tsuda-Tsukimoto M, et al. Characterization of hepatobiliary transport systems of a novel alpha4beta1/alpha4beta7 dual antagonist, TR-14035. Pharm Res. 2006 Nov;23(11):2646-56. Sircar I, et al. Synthesis and SAR of N-benzoyl-L-biphenylalanine derivatives: discovery of TR-14035, a dual alpha(4)beta(7)/alpha(4)beta(1) integrin antagonist. Bioorg Med Chem. 2002 Jun;10(6):2051-66. Egger LA, et al. Alpha(4)beta(7)/alpha(4)beta(1) dual integrin antagonists block alpha(4)beta(7)-dependent adhesion under shear flow. J Pharmacol Exp Ther. 2002 Jul;302(1):153-62.