TargetMol

WHI-P97 HCl 211555-05-4(free base)

Product Code:
 
TAR-T4657L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4657L-1mg1mg£117.00
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TAR-T4657L-2mg2mg£136.00
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TAR-T4657L-5mg5mg£152.00
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TAR-T4657L-1mL1 mL * 10 mM (in DMSO)£205.00
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TAR-T4657L-10mg10mg£228.00
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TAR-T4657L-25mg25mg£354.00
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TAR-T4657L-50mg50mg£460.00
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TAR-T4657L-100mg100mg£627.00
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Further Information

Bioactivity:
WHI-P97 HCl is a potent and selective JAK-3 inhibitor. WHI-P97 had an estimated Ki value of 0.09 microM from modeling studies and a measured IC50 value of 2.5 microM in EGFR kinase inhibition assays. WHI-P97 effectively inhibited the in vitro invasiveness of EGFR-positive human cancer cells in a concentration-dependent manner.
CAS:
T4657L
Formula:
C16H14Br2ClN3O3
Molecular Weight:
491.56
Pathway:
Stem Cells; Angiogenesis; JAK/STAT signaling; Chromatin/Epigenetic
Purity:
0.9902
SMILES:
COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C(=C3)Br)O)Br)OC.Cl
Target:
JAK

References

R Malaviya, et al. Treatment of allergic asthma by targeting janus kinase 3-dependent leukotriene synthesis in mast cells with 4-(3', 5'-dibromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P97). J Pharmacol Exp Ther. 2000 Dec;295(3):912-26.