TargetMol

TC-G-1008

Product Code:
 
TAR-T4648
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4648-1mg1mg£103.00
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TAR-T4648-2mg2mg£118.00
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TAR-T4648-1mL1 mL * 10 mM (in DMSO)£144.00
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TAR-T4648-5mg5mg£144.00
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TAR-T4648-10mg10mg£198.00
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TAR-T4648-25mg25mg£341.00
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TAR-T4648-50mg50mg£534.00
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TAR-T4648-100mg100mg£736.00
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TAR-T4648-500mg500mg£1,420.00
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Further Information

Bioactivity:
TC-G-1008 is a GPR39 (zinc receptor) agonist (EC50 values are 0.4 and 0.8 nM for rat and human receptors respectively).
CAS:
1621175-65-2
Formula:
C18H19ClN6O2S
Molecular Weight:
418.9
Pathway:
GPCR/G Protein
Purity:
0.99
SMILES:
CNc1nc(NCc2ccc(NS(C)(=O)=O)cc2Cl)cc(n1)-c1ccccn1
Target:
GHSR

References

Peukert S, et al. Discovery of 2-Pyridylpyrimidines as the First Orally Bioavailable GPR39 Agonists. ACS Med Chem Lett. 2014 Aug 4;5(10):1114-8. Shimizu Y, et al. Rho kinase-dependent desensitization of GPR39; a unique mechanism of GPCR downregulation. Biochem Pharmacol. 2017 Sep 15;140:105-114.