TargetMol

BMS-3

Product Code:
 
TAR-T4600
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1

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CodeSizePrice
TAR-T4600-1mg1mg£99.00
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TAR-T4600-2mg2mg£109.00
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TAR-T4600-1mL1 mL * 10 mM (in DMSO)£131.00
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TAR-T4600-5mg5mg£131.00
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TAR-T4600-10mg10mg£166.00
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TAR-T4600-25mg25mg£266.00
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TAR-T4600-50mg50mg£396.00
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TAR-T4600-100mg100mg£544.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively.
CAS:
1338247-30-5
Formula:
C17H12Cl2F2N4OS
Molecular Weight:
429.27
Pathway:
Cell Cycle/Checkpoint
Purity:
0.9931
SMILES:
FC(F)c1cc(-c2cnc(NC(=O)C3CC3)s2)n(n1)-c1c(Cl)cccc1Cl
Target:
LIM Kinase

References

Romarowski A, et al. PKA-dependent phosphorylation of LIMK1 and Cofilin is essential for mouse sperm acrosomal exocytosis. Dev Biol. 2015 Sep 15;405(2):237-49. Ross-Macdonald P, et al. Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors. Mol Cancer Ther. 2008 Nov;7(11):3490-8.