TargetMol

PFI-2 hydrochloride

Product Code:
 
TAR-T4583
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4583-1mg1mg£98.00
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TAR-T4583-2mg2mg£108.00
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TAR-T4583-5mg5mg£132.00
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TAR-T4583-10mg10mg£166.00
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TAR-T4583-1mL1 mL * 10 mM (in DMSO)£175.00
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TAR-T4583-25mg25mg£250.00
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TAR-T4583-50mg50mg£389.00
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TAR-T4583-100mg100mg£538.00
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TAR-T4583-500mg500mg£1,058.00
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This product comes from: United States.
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Further Information

Bioactivity:
PFI-2 hydrochloride is a potent, highly selective, and cell-active inhibitor of the methyltransferase activity of SETD7 (IC50: 2 nM), 500 fold active than (S)-PFI-2.
CAS:
1627607-87-7
Formula:
C23H26ClF4N3O3S
Molecular Weight:
535.98
Pathway:
Chromatin/Epigenetic
Purity:
0.9991
SMILES:
Cl.Fc1cc(cc2CCNCc12)S(=O)(=O)N[C@H](Cc1cccc(c1)C(F)(F)F)C(=O)N1CCCC1
Target:
Histone Methyltransferase

References

Barsyte-Lovejoy D, et al. (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12853-8.