TargetMol

Stiripentol

Product Code:
 
TAR-T4498
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4498-5mg5mg£108.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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TAR-T4498-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T4498-10mg10mg£131.00
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TAR-T4498-25mg25mg£193.00
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TAR-T4498-50mg50mg£245.00
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TAR-T4498-100mg100mg£365.00
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Quantity:
TAR-T4498-200mg200mg£507.00
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This product comes from: United States.
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Further Information

Bioactivity:
Stiripentol (STP) is an anticonvulsant agent, which can inhibit N-demethylation of CLB to NCLB mediated by CYP3A4 (noncompetitively) and CYP2C19 (competitively) with Ki of 1.59/0.516 μM and IC50 of 1.58/3.29 μM, respectively.
CAS:
49763-96-4
Formula:
C14H18O3
Molecular Weight:
234.295
Pathway:
Metabolism
Purity:
0.9993
SMILES:
CC(C)(C)C(O)C=Cc1ccc2OCOc2c1
Target:
P45

References

Avdeef A, Kansy M. Predicting Solubility of Newly-Approved Drugs (2016?2020) with a Simple ABSOLV and GSE (Flexible-Acceptor) Consensus Model Outperforming Random Forest Regression. Journal of Solution Chemistry. 2022: 1-36. Giraud C, et al. In vitro and in vivo inhibitory effect of stiripentol on clobazam metabolism.Drug Metab Dispos. 2006 Apr;34(4):608-11. Epub 2006 Jan 13. Cao D, et al. Efficacy of stiripentol in hyperthermia-induced seizures in a mouse model of Dravet syndrome. Epilepsia. 2012 Jul;53(7):1140-5.