TargetMol

PQ401 hydrochloride (196868-63-0(free base))

Product Code:
 
TAR-T4324
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4324-1mg1mg£100.00
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TAR-T4324-2mg2mg£111.00
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TAR-T4324-5mg5mg£125.00
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TAR-T4324-1mL1 mL * 10 mM (in DMSO)£147.00
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TAR-T4324-10mg10mg£147.00
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TAR-T4324-25mg25mg£206.00
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TAR-T4324-50mg50mg£314.00
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TAR-T4324-100mg100mg£475.00
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This product comes from: United States.
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Further Information

Bioactivity:
PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.
CAS:
T4324
Formula:
C18H17Cl2N3O2
Molecular Weight:
378.25
Pathway:
Tyrosine Kinase/Adaptors
Purity:
0.999
SMILES:
Cl.COc1ccc(Cl)cc1NC(=O)Nc1cc(C)nc2ccccc12
Target:
IGF-1R

References

Troib A,etal. The effects of type 1 IGF receptor inhibition in a mouse model of diabetic kidney disease. Growth Horm IGF Res. 2011 Oct;21(5):285-91. Gable KL,etal, Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth. Mol Cancer Ther. 2006 Apr;5(4):1079-86. Sanchez-Alavez M, Osborn O, Tabarean IV, Insulin-like growth factor 1-mediated hyperthermia involves anterior hypothalamic insulin receptors. J Biol Chem. 2011 Apr 29;286(17):14983-90.