TargetMol

BAY 61-3606

Product Code:
 
TAR-T4263
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4263-1mg1mg£111.00
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TAR-T4263-2mg2mg£128.00
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TAR-T4263-5mg5mg£185.00
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TAR-T4263-1mL1 mL * 10 mM (in DMSO)£222.00
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TAR-T4263-10mg10mg£266.00
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TAR-T4263-25mg25mg£389.00
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TAR-T4263-50mg50mg£547.00
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Further Information

Bioactivity:
BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM), exhibiting no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.
CAS:
732983-37-8
Formula:
C20H18N6O3
Molecular Weight:
390.403
Pathway:
Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
Purity:
0.9872
SMILES:
COc1ccc(cc1OC)-c1cc2nccn2c(Nc2ncccc2C(N)=O)n1
Target:
Apoptosis; Syk

References

Lau KS, et al. BAY61-3606 affects the viability of colon cancer cells in a genotype-directed manner. PLoS One. 2012;7(7):e41343. Yamamoto N, et al. The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents. J Pharmacol Exp Ther. 2003 Sep;306(3):1174-81