TargetMol

AZD3759 hydrochloride

Product Code:
 
TAR-T4249
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4249-1mg1mg£100.00
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TAR-T4249-2mg2mg£111.00
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TAR-T4249-5mg5mg£125.00
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TAR-T4249-1mL1 mL * 10 mM (in DMSO)£133.00
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TAR-T4249-10mg10mg£149.00
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TAR-T4249-25mg25mg£206.00
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TAR-T4249-50mg50mg£310.00
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TAR-T4249-100mg100mg£465.00
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TAR-T4249-500mg500mg£970.00
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This product comes from: United States.
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Further Information

Bioactivity:
AZD3759 (hydrochloride) is an effective, orally active and central nervous system-penetrant EGFR inhibitor. At Km ATP concentrations, the IC50s are 0.2/0.3/0.2 nM for EGFR (L858R)/EGFR (wt)/EGFR (exon 19Del).
CAS:
1626387-81-2
Formula:
C22H24Cl2FN5O3
Molecular Weight:
496.36
Pathway:
Tyrosine Kinase/Adaptors; JAK/STAT signaling; Angiogenesis
Purity:
0.9941
SMILES:
Cl.COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1OC(=O)N1CCN(C)C[C@H]1C
Target:
EGFR

References

Zeng Q, et al. Discovery and Evaluation of Clinicalal Candidate AZD3759, a Potent, Oral Active, Central Nervous System-Penetrant, Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor. J Med Chem. 2015 Oct 22;58(20):8200-15.