TargetMol

S1RA hydrochloride

Product Code:
 
TAR-T4229
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4229-1mg1mg£101.00
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TAR-T4229-2mg2mg£114.00
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TAR-T4229-5mg5mg£142.00
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TAR-T4229-1mL1 mL * 10 mM (in DMSO)£145.00
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TAR-T4229-10mg10mg£177.00
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TAR-T4229-25mg25mg£302.00
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TAR-T4229-50mg50mg£432.00
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TAR-T4229-100mg100mg£603.00
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TAR-T4229-500mg500mg£1,187.00
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Further Information

Bioactivity:
S1RA HCl (E-52862 HCl) is an effective and specific sigma-1 receptor(σ1R, Ki: 17 nM) antagonist, and has good selectivity against σ2R (Ki > 1000 nM).
CAS:
1265917-14-3
Formula:
C20H24ClN3O2
Molecular Weight:
373.88
Pathway:
GPCR/G Protein
Purity:
0.9978
SMILES:
Cl.Cc1cc(OCCN2CCOCC2)nn1-c1ccc2ccccc2c1
Target:
Sigma receptor

References

Meng F, Xiao Y, Ji Y, et al. An open-like conformation of the sigma-1 receptor reveals its ligand entry pathway. Nature Communications. 2022, 13(1): 1-11. Romero L, et al. Pharmacological properties of S1RA, a new sigma-1 receptor antagonist that inhibits neuropathic pain and activity-induced spinal sensitization. Br J Pharmacol. 2012 Aug;166(8):2289-306. Vidal-Torres A, et al. Effects of the selective sigma-1 receptor antagonist S1RA on formalin-induced pain behavior and neurotransmitter release in the spinal cord in rats. J Neurochem. 2014 Jan 3. D?az JL, et al. Synthesis and biological evaluation of the 1-arylpyrazole class of ?(1) receptor antagonists: identification of 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862). J Med Chem. 2012 Oct 11;55(19):8211-24.