TargetMol

SB1317 hydrochloride (1204918-72-8(free base))

Product Code:
 
TAR-T4227
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4227-1mg1mg£107.00
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TAR-T4227-2mg2mg£121.00
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TAR-T4227-5mg5mg£163.00
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TAR-T4227-1mL1 mL * 10 mM (in DMSO)£172.00
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TAR-T4227-10mg10mg£222.00
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TAR-T4227-25mg25mg£344.00
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TAR-T4227-50mg50mg£402.00
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TAR-T4227-100mg100mg£564.00
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Further Information

Bioactivity:
SB1317 is an effective inhibitor of CDK2/JAK2/FLT3 (IC50: 13/73/56 nM).
CAS:
T4227
Formula:
C23H25ClN4O
Molecular Weight:
408.92
Pathway:
Stem Cells; JAK/STAT signaling; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors; Angiogenesis
Purity:
0.9839
SMILES:
Cl.CN1CC=CCCOc2cccc(c2)-c2ccnc(Nc3cccc(C1)c3)n2
Target:
FLT; JAK; CDK

References

William AD, et al. Discovery of kinase spectrum selective macrocycle (16E)-14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a potent inhibitor of cyclin dependent kina Pasha MK, et al. PreClinicalal metabolism and pharmacokinetics of SB1317 (TG02), a potent CDK/JAK2/FLT3 inhibitor. Drug Metab Lett. 2012 Mar;6(1):33-42.