TargetMol

CP-724714

Product Code:
 
TAR-T4014
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4014-1mg1mg£100.00
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TAR-T4014-2mg2mg£113.00
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TAR-T4014-5mg5mg£140.00
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TAR-T4014-1mL1 mL * 10 mM (in DMSO)£144.00
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TAR-T4014-10mg10mg£198.00
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TAR-T4014-25mg25mg£301.00
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TAR-T4014-50mg50mg£454.00
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TAR-T4014-100mg100mg£629.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
CP-724714 is an effective and selective HER2/ErbB2 inhibitor (IC50: 10 nM), >640-fold selectivity against EGFR, Abl, InsR, PDGFR, IRG-1R, Src, VEGFR2, c-Met etc.
CAS:
383432-38-0
Formula:
C27H27N5O3
Molecular Weight:
469.545
Pathway:
JAK/STAT signaling; Apoptosis; Tyrosine Kinase/Adaptors; Angiogenesis
Purity:
0.991
SMILES:
COCC(=O)NCC=Cc1ccc2ncnc(Nc3ccc(Oc4ccc(C)nc4)c(C)c3)c2c1
Target:
Apoptosis; EGFR

References

Feng B, et al. Role of hepatic transporters in the disposition and hepatotoxicity of a HER2 tyrosine kinase inhibitor CP-724,714. Toxicol Sci, 2009, 108(2), 492-500. Jani JP, et al. Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor. Cancer Res, 2007, 67(20), 9887-9893.