TargetMol

Su1498

Product Code:
 
TAR-T3980
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3980-1mg1mg£98.00
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TAR-T3980-2mg2mg£108.00
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TAR-T3980-5mg5mg£128.00
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TAR-T3980-1mL1 mL * 10 mM (in DMSO)£134.00
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TAR-T3980-10mg10mg£168.00
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TAR-T3980-25mg25mg£275.00
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TAR-T3980-50mg50mg£402.00
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TAR-T3980-100mg100mg£567.00
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This product comes from: United States.
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Further Information

Bioactivity:
SU 1498 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 (VEGFR2, aka FLK1; IC50 = 700 nM), having negligible activity at several other serine/threonine and tyrosine kinases.1, 2 It effectively blocks signaling through VEGFR2 both in vitro and in vivo.1, 3 SU 1498 is used to study the role of VEGFR2 signaling in diverse processes, including angiogenesis, tumor growth, neural progenitor cell survival, and neuroregeneration.
CAS:
168835-82-3
Formula:
C25H30N2O2
Molecular Weight:
390.527
Pathway:
Angiogenesis; Tyrosine Kinase/Adaptors
Purity:
1
SMILES:
CC(C)c1cc(C=C(/C#N)C(=O)NCCCc2ccccc2)cc(C(C)C)c1O
Target:
VEGFR

References

Gawlak G, et al. Chronic high-magnitude cyclic stretch stimulates EC inflammatory response via VEGF receptor 2-dependent mechanism. Am J Physiol Lung Cell Mol Physiol. 2016 Jun 1;310(11):L1062-70.