TargetMol

Mivebresib

Product Code:
 
TAR-T3712
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3712-1mg1mg£113.00
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TAR-T3712-2mg2mg£131.00
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TAR-T3712-5mg5mg£149.00
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TAR-T3712-1mL1 mL * 10 mM (in DMSO)£151.00
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TAR-T3712-10mg10mg£201.00
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TAR-T3712-25mg25mg£287.00
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TAR-T3712-50mg50mg£461.00
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TAR-T3712-100mg100mg£629.00
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Further Information

Bioactivity:
Mivebresib, also known as ABBV-075, is a potent BET inhibitor (bromodomain (BRD)-containing protein) with potential antineoplastic activity. Upon administration, the bromodomain inhibitor ABBV-075 binds to the acetyl-lysine binding site in the BRD of certain BRD-containing protein(s), thereby preventing the interaction between those proteins and acetylated histones. This disrupts chromatin remodeling, prevents the expression of certain growth-promoting genes, and leads to an inhibition of cell growth in susceptible tumors. Also a potent inhibitor of MYC and the TMPRSS2-ETS fusion proteins.
CAS:
1445993-26-9
Formula:
C22H19F2N3O4S
Molecular Weight:
459.47
Pathway:
Apoptosis; Chromatin/Epigenetic
Purity:
0.9874
SMILES:
O=C1C=2NC=CC2C(=CN1C)C=3C=C(C=CC3OC4=CC=C(F)C=C4F)NS(=O)(=O)CC
Target:
Apoptosis; Epigenetic Reader Domain

References

Aparna Sarthy, et al. Experimental and Molecular Therapeutics. 2016, Abstract 4718.