TargetMol

SR9009

Product Code:
 
TAR-T3685
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3685-1mg1mg£95.00
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TAR-T3685-2mg2mg£109.00
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TAR-T3685-1mL1 mL * 10 mM (in DMSO)£121.00
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TAR-T3685-5mg5mg£121.00
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TAR-T3685-10mg10mg£149.00
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TAR-T3685-25mg25mg£201.00
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TAR-T3685-50mg50mg£302.00
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TAR-T3685-100mg100mg£445.00
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TAR-T3685-500mg500mg£930.00
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Further Information

Bioactivity:
SR9009, a REV-ERB agonist, increases the constitutive repression of genes regulated by REV-ERBα/ERBβ (IC50: 670/800 nM). Through activation of REV-ERB, SR9009 can decrease circadian locomotor activity during the dark phase and alter the expression pattern of core clock genes in the hypothalami of mice. The circadian pattern of expression of an array of metabolic genes in the liver, skeletal muscle, and adipose tissue was also altered in mice exposed to SR9009, resulting in increased energy expenditure. In Diet-induced obese mice, SR9009 (100 mg/kg, i.p., b.i.d., for 30 days) could decrease fat mass and markedly improve dyslipidemia and hyperglycemia.
CAS:
1379686-30-2
Formula:
C20H24ClN3O4S
Molecular Weight:
437.94
Pathway:
Autophagy
Purity:
0.998
SMILES:
CCOC(=O)N1CCC(CN(Cc2ccc(s2)[N+]([O-])=O)Cc2ccc(Cl)cc2)C1
Target:
Autophagy

References

Solt LA, et al. Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature. 2012 Mar 29;485(7396):62-68.