TargetMol

BMS-1

Product Code:
 
TAR-T3655
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3655-1mg1mg£109.00
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Quantity:
TAR-T3655-2mg2mg£127.00
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TAR-T3655-5mg5mg£160.00
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TAR-T3655-1mL1 mL * 10 mM (in DMSO)£165.00
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TAR-T3655-10mg10mg£221.00
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TAR-T3655-25mg25mg£352.00
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Quantity:
TAR-T3655-50mg50mg£475.00
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TAR-T3655-100mg100mg£659.00
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Quantity:
TAR-T3655-500mg500mg£1,299.00
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This product comes from: United States.
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Further Information

Bioactivity:
PD1-PD-L1 inhibitor 1 (PD1-PD-L1-IN-1) is an inhibitor of the PD1-PD-L1 protein-protein interaction. It also acts as an immunomodulator. Programmed death ligand 1 (PD-L1) is a protein in humans that is encoded by the CD274 gene and the upregulation of PD-L1 allows Ys to evade the host immune system. High tumor expression of PD-L1 was associated with increased tumor aggressiveness and a 4.5-fold increased risk of death.
CAS:
1675201-83-8
Formula:
C29H33NO5
Molecular Weight:
475.585
Pathway:
Cell Cycle/Checkpoint; Immunology/Inflammation; Apoptosis
Purity:
0.9986
SMILES:
COc1cc(OCc2cccc(c2C)-c2ccccc2)cc(OC)c1CN1CCCC[C@H]1C(O)=O
Target:
Apoptosis; PD-1/PD-L1

References

Chupak Louis S,et al. From PCT Int. Appl. (2015), WO 2015034820 A1 20150312. Choi J G, Kim Y S, Kim J H, et al. Anticancer effect of Salvia plebeia and its active compound by improving T-cell activity via blockade of PD-1/PD-L1 interaction in humanized PD-1 mouse model. Frontiers in immunology. 2020 Nov 5;11:598556. doi: 10.3389 Zhao Y, Hao C, Li M, et al. PD-1/PD-L1 inhibitor ameliorates silica-induced pulmonary fibrosis by maintaining systemic immune homeostasis. Biomedicine & Pharmacotherapy. 2022, 148: 112768. Choi J G, Kim Y S, Kim J H, et al. Anticancer effect of Salvia plebeia and its active compound by improving T-cell activity via blockade of PD-1/PD-L1 interaction in humanized PD-1 mouse model[J]. Frontiers in immunology,. 2020, 11.