TargetMol

HMN-176

Product Code:
 
TAR-T3643
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3643-1mg1mg£99.00
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TAR-T3643-2mg2mg£111.00
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TAR-T3643-1mL1 mL * 10 mM (in DMSO)£128.00
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TAR-T3643-5mg5mg£135.00
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TAR-T3643-10mg10mg£168.00
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TAR-T3643-25mg25mg£230.00
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TAR-T3643-50mg50mg£367.00
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TAR-T3643-100mg100mg£511.00
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TAR-T3643-500mg500mg£1,026.00
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Further Information

Bioactivity:
HMN-176 is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1).
CAS:
173529-10-7
Formula:
C20H18N2O4S
Molecular Weight:
382.43
Pathway:
Cell Cycle/Checkpoint
Purity:
0.9899
SMILES:
COc1ccc(cc1)S(=O)(=O)Nc1ccccc1C=Cc1cc[n+]([O-])cc1
Target:
PLK

References

Tanaka H, et al. HMN-176, an active metabolite of the synthetic antitumor agent HMN-214, restores chemosensitivity to multidrug-resistant cells by targeting the transcription factor NF-Y. Cancer Res. 2003 Oct 15;63(20):6942-7. Medina-Gundrum L, et al. Investigation of HMN-176 anticancer activity in human tumor specimens in vitro and the effects of HMN-176 on differential gene expression. Invest New Drugs. 2005 Jan;23(1):3-9. Takagi M, et al. In vivo antitumor activity of a novel sulfonamide, HMN-214, against human tumor xenografts in mice and the spectrum of cytotoxicity of its active metabolite, HMN-176. Invest New Drugs. 2003 Nov;21(4):387-99. DiMaio MA, et al. The small organic compound HMN-176 delays satisfaction of the spindle assembly checkpoint by inhibiting centrosome-dependent microtubule nucleation. Mol Cancer Ther. 2009 Mar;8(3):592-601.