TargetMol

Ivosidenib

Product Code:
 
TAR-T3617
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3617-2mg2mg£104.00
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TAR-T3617-5mg5mg£124.00
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TAR-T3617-1mL1 mL * 10 mM (in DMSO)£153.00
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TAR-T3617-10mg10mg£169.00
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TAR-T3617-25mg25mg£228.00
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TAR-T3617-50mg50mg£324.00
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TAR-T3617-100mg100mg£479.00
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This product comes from: United States.
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Further Information

Bioactivity:
Ivosidenib is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Ivosidenib specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhibits the formation of the oncometabolite, 2-hydroxyglutarate (2 hG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH1-expressing tumor cells.
CAS:
1448347-49-6
Formula:
C28H22ClF3N6O3
Molecular Weight:
582.97
Pathway:
Metabolism
Purity:
0.997
SMILES:
Fc1cncc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N
Target:
Dehydrogenase; Isocitrate Dehydrogenase (IDH)

References

Erica Hansen, et al. Blood. 2104, 124:3734.