TargetMol

SU4312

Product Code:
 
TAR-T3570
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3570-1mg1mg£98.00
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TAR-T3570-2mg2mg£108.00
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TAR-T3570-1mL1 mL * 10 mM (in DMSO)£134.00
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TAR-T3570-5mg5mg£135.00
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TAR-T3570-10mg10mg£182.00
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TAR-T3570-25mg25mg£278.00
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TAR-T3570-50mg50mg£394.00
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Further Information

Bioactivity:
SU-4312, also known as DMBI, is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 values are 0.8 and 19.4 μM respectively). SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS.
CAS:
5812-07-7
Formula:
C17H16N2O
Molecular Weight:
264.328
Pathway:
Tyrosine Kinase/Adaptors; Angiogenesis
Purity:
0.98
SMILES:
CN(C)c1ccc(C=C2C(=O)Nc3ccccc23)cc1
Target:
VEGFR; PDGFR

References

Li Y, et al. Vascular Endothelial Growth Factor-A (VEGF-A) Mediates Activin A-Induced Human Trophoblast Endothelial-Like Tube Formation. Endocrinology. 2015 Nov;156(11):4257-68. Cui W, et al. The anti-cancer agent SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS. Br J Pharmacol. 2013 Mar;168(5):1201-14.