TargetMol

Jervine

Product Code:
 
TAR-T3363
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3363-5mg5mg£122.00
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TAR-T3363-1mL1 mL * 10 mM (in DMSO)£125.00
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TAR-T3363-10mg10mg£168.00
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TAR-T3363-25mg25mg£290.00
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TAR-T3363-50mg50mg£492.00
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TAR-T3363-100mg100mg£675.00
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Quantity:
TAR-T3363-500mg500mg£1,291.00
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Further Information

Bioactivity:
The biological activity of Jervine is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened, which is an integral part of the Hedgehog signaling pathways. With smoothened inhibited, the GLI1 transcription cannot be activated and Hedgehog target genes cannot be transcribed.
CAS:
469-59-0
Formula:
C27H39NO3
Molecular Weight:
425.613
Pathway:
Stem Cells; GPCR/G Protein
Purity:
0.9986
SMILES:
[H][C@@]12NC[C@@H](C)C[C@H]1O[C@]1(CC[C@]3([H])C(C(=O)[C@@]4([H])[C@@]3([H])CC=C3C[C@@H](O)CC[C@]43C)=C1C)[C@@H]2C
Target:
Hedgehog/Smoothened; Smo

References

Campbell M, et al. Teratology. 1987, 36(2):235-43. ten Berge D, et al. Development. 2001, 128(15):2929-38.