TargetMol

Troglitazone

Product Code:
 
TAR-T3170
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
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CodeSizePrice
TAR-T3170-2mg2mg£99.00
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TAR-T3170-5mg5mg£115.00
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TAR-T3170-1mL1 mL * 10 mM (in DMSO)£132.00
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TAR-T3170-10mg10mg£143.00
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TAR-T3170-25mg25mg£211.00
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TAR-T3170-50mg50mg£329.00
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TAR-T3170-100mg100mg£543.00
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TAR-T3170-500mg500mg£1,058.00
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This product comes from: United States.
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Further Information

Bioactivity:
Troglitazone is a PPARγ agonist with anti-inflammatory and anti-tumor activity.
CAS:
97322-87-7
Formula:
C24H27NO5S
Molecular Weight:
441.54
Pathway:
Autophagy; DNA Damage/DNA Repair; Cell Cycle/Checkpoint; Metabolism; Apoptosis
Purity:
0.9962
SMILES:
Cc1c(C)c2OC(C)(COc3ccc(CC4SC(=O)NC4=O)cc3)CCc2c(C)c1O
Target:
Apoptosis; Ferroptosis; PPAR; Autophagy

References

1. Park JW, et al. Thyroid. 2005, 15(3):222-31. 2. Bolden A, et al. PPAR Res. 2012, 2012:929052. 3. Baek SJ, et al. J Biol Chem. 2003, 278(8):5845-53. 4. van Westerloo DJ, et al. Am J Pathol. 2005, 166(3):721-8. 5. Jaeschke H. Toxicol Sci. 2007, 97(1):1-3. 6. Fujita M, et al. In vitro and in vivo cytotoxicity of troglitazone in pancreatic cancer. J Exp Clin Cancer Res. 2017 Jul 3;36(1):91. 7. Nazim UM, et al. PPAR? activation by troglitazone enhances human lung cancer cells to TRAIL-induced apoptosis via autophagy flux. Oncotarget. 2017 Apr 18;8(16):26819-26831.