TargetMol

Salubrinal

Product Code:
 
TAR-T3045
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3045-2mg2mg£99.00
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TAR-T3045-5mg5mg£115.00
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TAR-T3045-1mL1 mL * 10 mM (in DMSO)£120.00
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TAR-T3045-10mg10mg£139.00
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TAR-T3045-25mg25mg£204.00
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TAR-T3045-50mg50mg£302.00
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TAR-T3045-100mg100mg£464.00
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TAR-T3045-500mg500mg£946.00
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This product comes from: United States.
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Further Information

Bioactivity:
Salubrinal, a phosphatases (PP1) inhibitor(IC50=1.7 μM), exhibits function on the eukaryotic translation initiation factor 2 subunit (eIF2α).
CAS:
405060-95-9
Formula:
C21H17Cl3N4OS
Molecular Weight:
479.8
Pathway:
Autophagy; Metabolism; Apoptosis; Microbiology/Virology
Purity:
0.9997
SMILES:
ClC(Cl)(Cl)C(NC(=S)Nc1cccc2cccnc12)NC(=O)C=Cc1ccccc1
Target:
Apoptosis; Phosphatase; PERK; Autophagy; HSV

References

1. Boyce M, et al. Science, 2005, 307(5711), 935-939. 2. Methippara MM, et al. Am J Physiol Regul Integr Comp Physiol, 2009, 296(1), 178-184. 3. Methippara M, Neuroscience, 2012, 209, 108-118. 4. Zhang J, Zhang P, Meng C, et al. The PERK Pathway Plays a Neuroprotective Role During the Early Phase of Secondary Brain Injury Induced by Experimental Intracerebral Hemorrhage[M]//. Subarachnoid Hemorrhage. Springer, Cham, 2020: 105-119. 5. Meng C, Zhang J, Dang B, et al. PERK pathway activation promotes intracerebral hemorrhage induced secondary brain injury by inducing neuronal apoptosis both in vivo and in vitro[J]. Frontiers in neuroscience. 2018 Feb 28;12:111.