TargetMol

PF-02413873

Product Code:
 
TAR-T28362
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28362-1mg1mg£98.00
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TAR-T28362-2mg2mg£107.00
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TAR-T28362-5mg5mg£135.00
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TAR-T28362-1mL1 mL * 10 mM (in DMSO)£142.00
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TAR-T28362-10mg10mg£173.00
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TAR-T28362-25mg25mg£282.00
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TAR-T28362-50mg50mg£409.00
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TAR-T28362-100mg100mg£575.00
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TAR-T28362-500mg500mg£1,155.00
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Further Information

Bioactivity:
PF-02413873 is a competitive antagonist of nonsteroidal progesterone receptor with a Ki of 2.6 nM. PF-02413873 can be used in studies about the treatment of gynecological conditions such as endometriosis.
CAS:
936345-35-6
Formula:
C18H21N3O3S
Molecular Weight:
359.44
Purity:
0.98
SMILES:
Cc1c(Oc2cc(C)c(C#N)c(C)c2)c(nn1CS(C)(=O)=O)C1CC1
Target:
Progesterone Receptor

References

1. Bungay PJ, et, al. Preclinical and clinical pharmacokinetics of PF-02413873, a nonsteroidal progesterone receptor antagonist. Drug Metab Dispos. 2011 Aug;39(8):1396-405. 2. Jones HM, et al. Application of PBPK modelling in drug discovery and development at Pfizer. Xenobiotica. 2012 Jan;42(1):94-106. 3. Howe DC, et, al. The translational efficacy of a nonsteroidal progesterone receptor antagonist, 4-[3-cyclopropyl-1-(mesylmethyl)-5-methyl-1H-pyrazol-4-yl]oxy,-2,6-dimethylbenzonitrile (PF-02413873), on endometrial growth in macaque and human. J Pharmacol Exp Ther. 2011 Nov;339(2):642-53.