TargetMol

GSK2606414

Product Code:
 
TAR-T2614
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2614-2mg2mg£119.00
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TAR-T2614-5mg5mg£147.00
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TAR-T2614-1mL1 mL * 10 mM (in DMSO)£149.00
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TAR-T2614-10mg10mg£174.00
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Quantity:
TAR-T2614-50mg50mg£351.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
GSK2606414 is an oral-available and specific PERK inhibitor (IC50=0.4 nM).
CAS:
1337531-36-8
Formula:
C24H20F3N5O
Molecular Weight:
451.453
Pathway:
Autophagy; Apoptosis
Purity:
0.98
SMILES:
Cn1cc(-c2ccc3N(CCc3c2)C(=O)Cc2cccc(c2)C(F)(F)F)c2c(N)ncnc12
Target:
Apoptosis; PERK; Autophagy

References

1. Axten JM, et al. J Med Chem. 2012, 55(16), 7193-7207. 2. Zhang J, Zhang P, Meng C, et al. Subarachnoid Hemorrhage. Springer, Cham. 2020: 105-119. 3. Kong F, Zou H, Liu X, et al. miR-7112-3p targets PERK to regulate the endoplasmic reticulum stress pathway and apoptosis induced by photodynamic therapy in colorectal cancer CX-1 cells[J]. Photodiagnosis and Photodynamic Therapy. 2020: 101663. 4. Meng C, Zhang J, Dang B, et al. PERK pathway activation promotes intracerebral hemorrhage induced secondary brain injury by inducing neuronal apoptosis both in vivo and in vitro[J]. Frontiers in neuroscience. 2018 Feb 28;12:111.