TargetMol

GS143

Product Code:
 
TAR-T25465
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T25465-1mg1mg£101.00
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TAR-T25465-2mg2mg£114.00
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TAR-T25465-5mg5mg£142.00
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TAR-T25465-1mL1 mL * 10 mM (in DMSO)£144.00
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TAR-T25465-10mg10mg£183.00
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TAR-T25465-25mg25mg£302.00
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TAR-T25465-50mg50mg£436.00
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TAR-T25465-100mg100mg£614.00
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TAR-T25465-500mg500mg£1,219.00
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Further Information

Bioactivity:
GS143 is a selec-tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 sup-presses NF-κB acti-va-tion and tran-scrip-tion of tar-get genes and does not inhibit proteasome activity. GS143 has anti-asthma effect
CAS:
916232-21-8
Formula:
C28H19FN2O4
Molecular Weight:
466.468
Pathway:
Ubiquitination; NF-κb
Purity:
0.9972
SMILES:
OC(=O)c1ccc(cc1)N1N=C(Cc2ccccc2)C(=C/c2ccc(o2)-c2ccccc2F)C1=O
Target:
IκB/IKK; E1/E2/E3 Enzyme; NF-κB

References

1. Rashmi BS, Gayathri D. Molecular characterization of gluten hydrolysing Bacillus sp. and their efficacy and biotherapeutic potential as probiotics using Caco-2 cell line. J Appl Microbiol. 2017 Sep;123(3):759-772. doi: 10.1111/jam.13517. Epub 2017 Aug 4. PubMed PMID: 28637081. 2. Chen S, Wei YJ, Chen MM, Zhang ZT. Bilateral treatment: a strategy for enhancing the mechanical strength of machinable veneers. Dent Mater. 2010 Oct;26(10):961-7. doi: 10.1016/j.dental.2010.05.011. Epub 2010 Jul 23. PubMed PMID: 20655583. 3. Hirose K, Wakashin H, Oki M, Kagami S, Suto A, Ikeda K, Watanabe N, Iwamoto I, Furuichi Y, Nakajima H. GS143, an IkappaB ubiquitination inhibitor, inhibits allergic airway inflammation in mice. Biochem Biophys Res Commun. 2008 Sep 26;374(3):507-11. doi: 10.1016/j.bbrc.2008.07.072. Epub 2008 Jul 24. PubMed PMID: 18656449. 4. Nakajima H, Fujiwara H, Furuichi Y, Tanaka K, Shimbara N. A novel small-molecule inhibitor of NF-kappaB signaling. Biochem Biophys Res Commun. 2008 Apr 18;368(4):1007-13. doi: 10.1016/j.bbrc.2008.01.166. Epub 2008 Feb 12. PubMed PMID: 18275844.