TargetMol

IHR-1

Product Code:
 
TAR-T24159
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24159-1mg1mg£109.00
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TAR-T24159-2mg2mg£125.00
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TAR-T24159-5mg5mg£149.00
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TAR-T24159-10mg10mg£185.00
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TAR-T24159-25mg25mg£275.00
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Quantity:
TAR-T24159-50mg50mg£362.00
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Quantity:
TAR-T24159-100mg100mg£503.00
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Quantity:
TAR-T24159-500mg500mg£1,018.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
IHR-1 is a Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro.
CAS:
548779-60-8
Formula:
C20H12Cl4N2O2
Molecular Weight:
454.12
Pathway:
Stem Cells
Purity:
0.986
SMILES:
C1=CC(=CC=C1NC(=O)C2=C(C=CC(=C2)Cl)Cl)NC(=O)C3=C(C=CC(=C3)Cl)Cl
Target:
Smo

References

1. Fan C W , Chen B , Franco I , et al. The Hedgehog Pathway Effector Smoothened Exhibits Signaling Competency in the Absence of Ciliary Accumulation[J]. Cell Chemical Biology, 2014, 21(12):1680-1689.