TargetMol

BMS-754807

Product Code:
 
TAR-T2349
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2349-1mg1mg£107.00
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TAR-T2349-2mg2mg£122.00
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TAR-T2349-5mg5mg£148.00
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TAR-T2349-1mL1 mL * 10 mM (in DMSO)£165.00
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TAR-T2349-10mg10mg£206.00
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TAR-T2349-25mg25mg£348.00
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TAR-T2349-50mg50mg£524.00
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TAR-T2349-100mg100mg£724.00
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Further Information

Bioactivity:
Dual IGF-1R/InsR Inhibitor BMS-754807 is an oral small molecule inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine kinases with potential antineoplastic activity.
CAS:
1001350-96-4
Formula:
C23H24FN9O
Molecular Weight:
461.49
Pathway:
Tyrosine Kinase/Adaptors
Purity:
0.98
SMILES:
C[C@]1(CCCN1c1nn2cccc2c(n1)Nc1n[nH]c(c1)C1CC1)C(=O)Nc1cnc(cc1)F
Target:
Trk receptor; c-Met/HGFR; IGF-1R

References

1. Carboni JM, et al. Mol Cancer Ther, 2009, 8(12), 3341-3349. 2. Wittman MD, et al. J Med Chem, 2009, 52(23), 7360-7363. 3. Kolb EA, et al. Pediatr Blood Cancer, 2011, 56(4), 595-603. 4. Silbermann K, Stefan S, Elshawadfy R, et al. Identification of Thienopyrimidine Scaffold as Inhibitor of the ABC Transport Protein ABCC1 (MRP1) and Related Transporters Using a Combined Virtual Screening Approach[J]. Journal of Medicinal Chemistry. 2019.