TargetMol

KW-2449

Product Code:
 
TAR-T2341
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2341-2mg2mg£97.00
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TAR-T2341-5mg5mg£112.00
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TAR-T2341-1mL1 mL * 10 mM (in DMSO)£114.00
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TAR-T2341-10mg10mg£128.00
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TAR-T2341-25mg25mg£189.00
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TAR-T2341-50mg50mg£290.00
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TAR-T2341-100mg100mg£479.00
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TAR-T2341-500mg500mg£978.00
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This product comes from: United States.
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Further Information

Bioactivity:
KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 (IC50: 6.6 nM), modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.
CAS:
1000669-72-6
Formula:
C20H20N4O
Molecular Weight:
332.407
Pathway:
Stem Cells; Tyrosine Kinase/Adaptors; Chromatin/Epigenetic; Cell Cycle/Checkpoint; Cytoskeletal Signaling; Angiogenesis; Apoptosis; JAK/STAT signaling
Purity:
0.9989
SMILES:
O=C(N1CCNCC1)c1ccc(C=Cc2n[nH]c3ccccc23)cc1
Target:
Apoptosis; FGFR; FLT; JAK; Bcr-Abl; Src; c-Kit; Aurora Kinase

References

1. Shiotsu Y, et al. Blood, 2009, 114(8), 1607-17. 2. Pratz KW, et al. Blood, 2009, 113(17), 3938-46. 3. Nguyen T, et al. Clin Cancer Res, 2011, 17(10), 3219-32.