TargetMol

ML351

Product Code:
 
TAR-T21902
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T21902-1mg1mg£115.00
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TAR-T21902-2mg2mg£136.00
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TAR-T21902-5mg5mg£172.00
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TAR-T21902-1mL1 mL * 10 mM (in DMSO)£189.00
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TAR-T21902-10mg10mg£237.00
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TAR-T21902-25mg25mg£430.00
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TAR-T21902-50mg50mg£599.00
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TAR-T21902-100mg100mg£824.00
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TAR-T21902-500mg500mg£1,589.00
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This product comes from: United States.
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Further Information

Bioactivity:
ML351 is a potent and selective inhibitor of human 15-lipoxygenase-1 (15 LOX)(IC50: 200 nM).
CAS:
847163-28-4
Formula:
C15H11N3O
Molecular Weight:
249.273
Pathway:
Metabolism
Purity:
0.9786
SMILES:
CNc1oc(nc1C#N)-c1cccc2ccccc12
Target:
Lipoxygenase

References

1. Rai G, Joshi N, Perry S, et al. Discovery of ML351, a Potent and Selective Inhibitor of Human 15-Lipoxygenase-1. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-2013 Apr 15 [updated 2014 Jan 13]. 2. Rai G, Joshi N, Jung JE, et al. Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies. J Med Chem. 2014 May 22;57(10):4035-48. 3. Gaffney BJ. Lipoxygenases: structural principles and spectroscopy. Annu Rev Biophys Biomol Struct. 1996;25:431-59.