TargetMol

DC_AC50

Product Code:
 
TAR-T21876
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T21876-2mg2mg£104.00
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TAR-T21876-5mg5mg£125.00
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TAR-T21876-1mL1 mL * 10 mM (in DMSO)£131.00
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TAR-T21876-10mg10mg£155.00
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TAR-T21876-25mg25mg£230.00
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TAR-T21876-50mg50mg£321.00
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TAR-T21876-100mg100mg£446.00
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Further Information

Bioactivity:
DC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones). Inhibiting intracellular copper chaperones as a means of reducing/preventing acquired chemotherapy resistance.DC_AC50 binding to Atox1 and CCS and reducing cancer cell proliferation and tumour growth.
CAS:
497061-48-0
Formula:
C17H12BrF2N3OS
Molecular Weight:
424.26
Pathway:
Apoptosis;
Purity:
0.999
SMILES:
Nc1c(sc2nc3CCCc3cc12)C(=O)Nc1c(F)cc(F)cc1Br
Target:
Apoptosis;

References

1. Jordon M Inkol, et al. Inhibition of copper chaperones sensitizes human and canine osteosarcoma cells to carboplatin chemotherapy. Vet Comp Oncol. 2020 Dec;18(4):559-569. 2. Jing Wang, et al. Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation. Nat Chem. 2015 Dec;7(12):968-79.