TargetMol

CGP 3466B maleate

Product Code:
 
TAR-T21792
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T21792-2mg2mg£107.00
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TAR-T21792-5mg5mg£129.00
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Quantity:
TAR-T21792-1mL1 mL * 10 mM (in DMSO)£133.00
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Further Information

Bioactivity:
Omigapil maleate is an orally bioavailable GAPDH nitrosylation inhibitor. Omigapil maleate abrogates Aβ1-42-induced tau acetylation, memory impairment, and locomotor dysfunction in mice. Omigapil maleate has the potential for the research of Alzheimer's disease. Omigapil maleate (CGP3446B maleate) is a apoptosis inhibitor. Omigapil maleate can be used for the research of congenital muscular dystrophy (CMD).
CAS:
200189-97-5
Formula:
C23H21NO5
Molecular Weight:
391.42
Pathway:
Apoptosis
Purity:
0.9896
SMILES:
C(=CC(O)=O)C(O)=O.C(N(CC#C)C)C=1C=2C(OC=3C(C1)=CC=CC3)=CC=CC2
Target:
Apoptosis

References

1. Sarina Meinen, et al. Apoptosis inhibitors and mini-agrin have additive benefits in congenital muscular dystrophy mice. EMBO Mol Med. 2011 Aug;3(8):465-79. 2. Tanusree Sen, et al. Nitrosylation of GAPDH augments pathological tau acetylation upon exposure to amyloid-?. Sci Signal. 2018 Mar 20;11(522):eaao6765.